ALKBH1 antibody (AA 110-389)

Catalog No. ABIN7143716

Product Details anti-ALKBH1 Antibody

Target: ALKBH1 (AlkB, Alkylation Repair Homolog 1 (ALKBH1))

Binding Specificity: AA 110-389

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALKBH1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Alkylated DNA repair protein alkB homolog 1 protein (110-389AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ALKBH1

Target: ALKBH1 (AlkB, Alkylation Repair Homolog 1 (ALKBH1))

Alternative Name: ALKBH1 (ALKBH1 Products)

Background:

Background: Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron.

Aliases: ABH antibody, ABH1 antibody, alkB antibody, alkB homolog 1 histone H2A dioxygenase antibody, AlkB, alkylation repair homolog 1 (E. coli) antibody, ALKB1_HUMAN antibody, ALKBH antibody, ALKBH1 antibody, Alkylated DNA repair protein alkB homolog 1 antibody, Alkylation repair homolog 1 antibody, Alkylation repair, alkB homolog antibody, Alpha-ketoglutarate-dependent dioxygenase ABH1 antibody, DNA lyase ABH1 antibody, DNA oxidative demethylase ALKBH1 antibody, hABH antibody

UniProt: Q13686

Pathways: DNA Damage Repair