AFF4 antibody (AA 77-334) (Biotin)

Catalog No. ABIN7143567

Product Details anti-AFF4 Antibody (Biotin)

Target: AFF4 (AF4/FMR2 Family, Member 4 (AFF4))

Binding Specificity: AA 77-334

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AFF4 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human AF4/FMR2 family member 4 protein (77-334AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for AFF4

Target: AFF4 (AF4/FMR2 Family, Member 4 (AFF4))

Alternative Name: AFF4 (AFF4 Products)

Synonyms: AFF4 antibody, RA_m002_jsmFBA6Br antibody, AF5Q31 antibody, MCEF antibody, Alf4 antibody, Laf4l antibody, AF4/FMR2 family member 4 L homeolog antibody, AF4/FMR2 family member 4 antibody, AF4/FMR2 family, member 4 antibody, aff4.L antibody, AFF4 antibody, aff4 antibody, Aff4 antibody

Background:

Background: Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression.

Aliases: AFF4 antibody, AF5Q31 antibody, MCEF antibody, HSPC092 antibody, AF4/FMR2 family member 4 antibody, ALL1-fused gene from chromosome 5q31 protein antibody, Protein AF-5q31 antibody, Major CDK9 elongation factor-associated protein antibody

UniProt: Q9UHB7