Actin-Like 6B antibody (AA 1-280)
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- Target See all Actin-Like 6B (ACTL6B) Antibodies
- Actin-Like 6B (ACTL6B)
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Binding Specificity
- AA 1-280
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Actin-Like 6B antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- Cross-Reactivity
- Human
- Purification
- Antigen Affinity Purified
- Immunogen
- Recombinant Human Actin-like protein 6B protein (1-280AA)
- Isotype
- IgG
- Top Product
- Discover our top product ACTL6B Primary Antibody
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- Application Notes
- Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- Actin-Like 6B (ACTL6B)
- Alternative Name
- ACTL6B (ACTL6B Products)
- Synonyms
- MGC110167 antibody, zgc:110167 antibody, ACTL6 antibody, BAF53B antibody, Actl6 antibody, ArpNa antibody, Baf53b antibody, actin-like 6B antibody, actin like 6B antibody, actl6b antibody, ACTL6B antibody, Actl6b antibody
- Background
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Background: Belongs to the chromatin remodeling brain-specific BAF (bBAF) complex, as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth .
Aliases: 53 kDa BRG1 associated factor B antibody, 53 kDa BRG1-associated factor B antibody, ACL 6B antibody, ACL6B antibody, ACL6B_HUMAN antibody, Actin like 6 antibody, Actin like protein 6B antibody, Actin like protein6B antibody, Actin related protein antibody, Actin related protein Baf53b antibody, actin-like 6B antibody, Actin-like protein 6B antibody, Actin-related protein Baf53b antibody, Actl 6 antibody, ACTL 6B antibody, Actl6 antibody, ACTL6 B antibody, Actl6b antibody, Arp Na antibody, ArpN a antibody, ArpN alpha antibody, ArpNa antibody, ArpNalpha antibody, Baf 53b antibody, BAF53B antibody, BRG1-associated factor 53B antibody
- UniProt
- O94805
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