AKAP1 antibody (AA 413-662)

Catalog No. ABIN7142902

Product Details anti-AKAP1 Antibody

Target: AKAP1 (A Kinase (PRKA) Anchor Protein 1 (AKAP1))

Binding Specificity: AA 413-662

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AKAP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human A-kinase anchor protein 10, mitochondrial protein (413-662AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for AKAP1

Target: AKAP1 (A Kinase (PRKA) Anchor Protein 1 (AKAP1))

Alternative Name: AKAP1 (AKAP1 Products)

Synonyms: AKAP1 antibody, akap1 antibody, fa08b04 antibody, wu:fa08b04 antibody, AKAP antibody, AKAP121 antibody, AKAP149 antibody, AKAP84 antibody, D-AKAP1 antibody, PPP1R43 antibody, PRKA1 antibody, SAKAP84 antibody, TDRD17 antibody, Akap antibody, C76494 antibody, C81186 antibody, DAKAP1 antibody, S-AKAP84 antibody, Akap84 antibody, A-kinase anchoring protein 1 antibody, A kinase (PRKA) anchor protein 1b antibody, A kinase (PRKA) anchor protein 1 antibody, AKAP1 antibody, akap1b antibody, akap1 antibody, Akap1 antibody

Background:

Background: Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity).

Aliases: AKAP10A-kinase anchor protein 10 antibody, mitochondrial antibody, AKAP-10 antibody, Dual specificity A kinase-anchoring protein 2 antibody, D-AKAP-2 antibody, Protein kinase A-anchoring protein 10 antibody, PRKA10 antibody

UniProt: O43572

Pathways: Synaptic Membrane