ERI1 antibody (AA 2-66)

Catalog No. ABIN7142343

Product Details anti-ERI1 Antibody

Target: ERI1 (Exoribonuclease 1 (ERI1))

Binding Specificity: AA 2-66

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERI1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Human 3\\\'-5\\\' exoribonuclease 1 protein (2-66AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ERI1

Target: ERI1 (Exoribonuclease 1 (ERI1))

Alternative Name: ERI1 (ERI1 Products)

Synonyms: THEX1 antibody, thex1 antibody, zgc:110635 antibody, hexo antibody, Eri-1 antibody, 3'HEXO antibody, HEXO antibody, 3'hexo antibody, 3110010F15Rik antibody, Thex1 antibody, eri-1 antibody, RGD1308378 antibody, exoribonuclease 1 antibody, three prime repair exonuclease 1 antibody, exoribonuclease 1 L homeolog antibody, 3'-5' exonuclease eri-1 antibody, ERI1 antibody, CpipJ_CPIJ003945 antibody, eri1 antibody, eri1.L antibody, Eri1 antibody, eri-1 antibody

Background:

Background: RNA exonuclease that binds to the 3\\\'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2\\\' and 3\\\'-hydroxyl groups at the last nucleotide of the histone 3\\\'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3\\\'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5\\\'-ACCCA-3\\\' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3\\\'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.

Aliases: 3' 5' exonuclease ERI 1 antibody, 3' 5' exonuclease ERI1 antibody, 3' EXO antibody, 3' exoribonuclease antibody, 3' HEXO antibody, 3' histone mRNA exonuclease 1 antibody, 3''-5'' exonuclease eri1 antibody, 3''-5'' exoribonuclease 1 antibody, 3'EXO antibody, 3'HEXO antibody, ERI 1 antibody, Eri 1 homolog antibody, Eri-1 homolog antibody, eri1 antibody, Eri1 homolog antibody, ERI1_HUMAN antibody, HEXO antibody, Histone mRNA 3' end specific exonuclease antibody, Histone mRNA 3' end specific exoribonuclease antibody, Histone mRNA 3''-end-specific exoribonuclease antibody, Histone mRNA 3''-exonuclease 1 antibody, MGC35395 antibody, Protein 3''hExo antibody, THEX 1 antibody, THEX1 antibody, Three prime histone mRNA exonuclease 1 antibody

UniProt: Q8IV48