PSMD1 antibody (Regulatory Subunit 10) (HRP)
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- Target See all PSMD1 Antibodies
- PSMD1 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 1 (PSMD1))
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Binding Specificity
- AA 1-226, Regulatory Subunit 10
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PSMD1 antibody is conjugated to HRP
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Application
- ELISA
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human 26S proteasome non-ATPase regulatory subunit 10 protein (1-226AA)
- Isotype
- IgG
- Top Product
- Discover our top product PSMD1 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- PSMD1 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 1 (PSMD1))
- Alternative Name
- PSMD1 (PSMD1 Products)
- Synonyms
- P112 antibody, Rpn2 antibody, S1 antibody, 2410026J11Rik antibody, zgc:55818 antibody, psmd1 antibody, proteasome 26S subunit, non-ATPase 1 antibody, proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 antibody, proteasome 26S subunit, non-ATPase 1 L homeolog antibody, PSMD1 antibody, Psmd1 antibody, psmd1 antibody, psmd1.L antibody
- Background
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Background: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis. Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export.
Aliases: 26S proteasome non-ATPase regulatory subunit 10 antibody, 26S proteasome regulatory subunit p28 antibody, Ankyrin repeat protein antibody, dJ889N15.2 antibody, Gankyrin antibody, Hepatocellular carcinoma-associated protein p28 II antibody, p28 antibody, p28(GANK) antibody, Proteasome (prosome, macropain) 26S subunit, non ATPase, 10 antibody, Proteasome 26S S10 antibody, PSD10_HUMAN antibody, Psmd10 antibody
- UniProt
- O75832
- Pathways
- Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway
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