ACMSD antibody (AA 33-129)

Catalog No. ABIN7142142

Product Details anti-ACMSD Antibody

Target: ACMSD (Aminocarboxymuconate Semialdehyde Decarboxylase (ACMSD))

Binding Specificity: AA 33-129

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACMSD antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Human 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase protein (33-129AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ACMSD

Target: ACMSD (Aminocarboxymuconate Semialdehyde Decarboxylase (ACMSD))

Alternative Name: ACMSD (ACMSD Products)

Synonyms: zgc:162888 antibody, ACMSD antibody, aminocarboxymuconate semialdehyde decarboxylase antibody, aminocarboxymuconate semialdehyde decarboxylase S homeolog antibody, amino carboxymuconate semialdehyde decarboxylase antibody, ACMSD antibody, acmsd antibody, acmsd.S antibody, Acmsd antibody

Background:

Background: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.

Aliases: 2 amino 3 carboxymuconate 6 semialdehyde decarboxylase antibody, 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase antibody, acmsd antibody, ACMSD_HUMAN antibody, Aminocarboxymuconate semialdehyde decarboxylase antibody, Picolinate carboxylase antibody

UniProt: Q8TDX5