PLCz1 antibody (AA 1-415)

Catalog No. ABIN7142062

Product Details anti-PLCz1 Antibody

Target: PLCz1 (Phospholipase C zeta 1 (PLCz1))

Binding Specificity: AA 1-415

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLCz1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Cross-Reactivity: Human, Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 protein (1-415AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PLCz1

Target: PLCz1 (Phospholipase C zeta 1 (PLCz1))

Alternative Name: PLCZ1 (PLCz1 Products)

Synonyms: PLC-zeta-1 antibody, PLCZ1 antibody, 1700041H07Rik antibody, PLCzeta antibody, NYD-SP27 antibody, PLCZ antibody, phospholipase C zeta 1 antibody, phospholipase C, zeta 1 antibody, PLCZ1 antibody, Plcz1 antibody

Background:

Background: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.

Aliases: 1 phosphatidylinositol 4,5 bisphosphate phosphodiesterase zeta 1 antibody, 1-phosphatidylinositol-4 antibody, 5-bisphosphate phosphodiesterase zeta-1 antibody, MGC149685 antibody, NYD SP27 antibody, Phosphoinositide phospholipase C zeta 1 antibody, Phosphoinositide phospholipase C-zeta-1 antibody, Phospholipase C zeta 1 antibody, Phospholipase C-zeta-1 antibody, PI phospholipase C zeta 1 antibody, PLC zeta 1 antibody, PLC-zeta-1 antibody, PLCZ1 antibody, PLCZ1_HUMAN antibody, PLCzeta antibody, Testis development protein NYD SP27 antibody, Testis development related NYD SP27 antibody, Testis-development protein NYD-SP27 antibody

UniProt: Q86YW0