PLCD4 antibody (AA 1-290)

Catalog No. ABIN7142053

Product Details anti-PLCD4 Antibody

Target: PLCD4 (Phospholipase C, delta 4 (PLCD4))

Binding Specificity: AA 1-290

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLCD4 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 protein (1-290AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PLCD4

Target: PLCD4 (Phospholipase C, delta 4 (PLCD4))

Alternative Name: PLCD4 (PLCD4 Products)

Synonyms: PLCD4 antibody, PLCL3 antibody, si:dkeyp-84a8.7 antibody, 4921507K24Rik antibody, phospholipase C eta 1 antibody, phospholipase C delta 4 antibody, phospholipase C, delta 4a antibody, phospholipase C, delta 4 antibody, phospholipase C delta 4 L homeolog antibody, PLCH1 antibody, PLCD4 antibody, plcd4a antibody, plcd4 antibody, Plcd4 antibody, plcd4.L antibody

Background:

Background: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.

Aliases: 1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase delta 4 antibody, 1-phosphatidylinositol 4 antibody, 1-phosphatidylinositol-4 antibody, 5-bisphosphate phosphodiesterase delta-4 antibody, hPLCD4 antibody, MGC12837 antibody, Phosphoinositide phospholipase C delta 4 antibody, Phosphoinositide phospholipase C-delta-4 antibody, Phospholipase C delta 4 antibody, Phospholipase C-delta-4 antibody, PLC delta 4 antibody, PLC delta4 antibody, PLC-delta-4 antibody, PLCD4 antibody, PLCD4_HUMAN antibody

UniProt: Q9BRC7

Pathways: Inositol Metabolic Process