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Genome Polyprotein (LOC100493440) (AA 192-325) antibody

LOC100493440 Reactivity: Hepatitis C Virus (HCV) ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7141946
  • Target See all Genome Polyprotein (LOC100493440) Antibodies
    Genome Polyprotein (LOC100493440)
    Binding Specificity
    • 8
    • 6
    • 5
    AA 192-325
    Reactivity
    • 9
    • 5
    • 5
    • 5
    • 4
    Hepatitis C Virus (HCV)
    Host
    • 28
    Rabbit
    Clonality
    • 28
    Polyclonal
    Conjugate
    • 10
    • 7
    • 6
    • 5
    Un-conjugated
    Application
    • 24
    • 3
    ELISA
    Cross-Reactivity
    Hepatitis C Virus (HCV)
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Hepatitis C virus genotype 1a Genome polyprotein protein (192-325AA)
    Isotype
    IgG
    Top Product
    Discover our top product LOC100493440 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    Genome Polyprotein (LOC100493440)
    Alternative Name
    Genome polyprotein (LOC100493440 Products)
    Synonyms
    JEV polyprotein antibody, polyprotein precursor antibody, Genome polyprotein antibody, flavivirus polyprotein gene antibody, YFVgp1 antibody
    Target Type
    Viral Protein
    Background

    Background: Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways and apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. Thought to play a role in virus-mediated cell transformation leading to hepatocellular carcinomas. Interacts with, and activates STAT3 leading to cellular transformation. May repress the promoter of p53, and sequester CREB3 and SP110 isoform 3/Sp110b in the cytoplasm. Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation. Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, and activates AP-1. Could mediate apoptotic pathways through association with TNF-type receptors TNFRSF1A and LTBR, although its effect on death receptor-induced apoptosis remains controversial. Enhances TRAIL mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury. Seric core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation. May transactivate human MYC, Rous sarcoma virus LTR, and SV40 promoters. May suppress the human FOS and HIV-1 LTR activity. Alters lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage. Core protein induces up-regulation of FAS promoter activity, and thereby probably contributes to the increased triglyceride accumulation in hepatocytes (steatosis) (By similarity).

    Aliases: Genome polyprotein [Cleaved into: Core protein p21 antibody, Capsid protein C antibody, p21), Core protein p19, Envelope glycoprotein E1 antibody, gp32 antibody, gp35), Envelope glycoprotein E2 antibody, NS1 antibody, gp68 antibody, gp70), p7, Protease NS2-3 antibody, p23 antibody, EC 3.4.22.-), Serine protease NS3 antibody, EC 3.4.21.98 antibody, EC 3.6.1.15 antibody, EC 3.6.4.13 antibody, Hepacivirin antibody, NS3P antibody, p70), Non-structural protein 4A antibody, NS4A antibody, p8), Non-structural protein 4B antibody, NS4B antibody, p27), Non-structural protein 5A antibody, NS5A antibody, p56), RNA-directed RNA polymerase antibody, EC 2.7.7.48 antibody, NS5B antibody, p68)] antibody

    UniProt
    P26664
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