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CD14 antibody

CD14 Reactivity: Human IHC, ELISA Host: Mouse Monoclonal 1A3B6 unconjugated
Catalog No. ABIN7140933
  • Target See all CD14 Antibodies
    CD14
    Reactivity
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    Human
    Host
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    Mouse
    Clonality
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    Monoclonal
    Conjugate
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    This CD14 antibody is un-conjugated
    Application
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    Immunohistochemistry (IHC), ELISA
    Cross-Reactivity
    Human
    Purification
    Protein G purified
    Immunogen
    Recombinant CD14 Protein
    Clone
    1A3B6
    Isotype
    IgG2b
    Top Product
    Discover our top product CD14 Primary Antibody
  • Application Notes
    Recommended dilution:IHC:1:50-1:500,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    CD14
    Alternative Name
    CD14 (CD14 Products)
    Synonyms
    CD14 molecule antibody, CD14 antigen antibody, CD14 antibody, Cd14 antibody
    Background

    Background: As a component of the innate immune system, the cell surface glycoprotein CD14 is a myelomonocytic differentiation antigen preferentially expressed on monocytes, macrophages, and activated granulocytes. CD14 exists as two forms, either anchored into the membrane by a GPI-anchor tail (mCD14) or present as a soluble form (sCD14) in normal serum and body fluids. CD14 was first described as a pattern recognition receptor for lipopolysaccharide (LPS) and a variety of ligands derived from different microbial sources, along with the co-receptors Toll-like receptor TLR 4 and MD-2. The binding of CD14 and LPS depends on the presence and catalytic activity of lipopolysaccharide-binding protein (LBP). Besides its endotoxin signaling function, CD14 has been proposed to be involved in various biological processes, including transportation of other lipids, cell-cell interaction during different immune responses, as well as recognition of apoptotic cells. Multiple transcript variants resulting from alternative splicing encode the same isoform of CD14.

    Aliases: CD14, CD14 Molecule

    UniProt
    P08571
    Pathways
    TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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