IFNK antibody (AA 24-195) (Biotin)

Catalog No. ABIN7140831

Product Details anti-IFNK Antibody (Biotin)

Target: IFNK (Interferon, kappa (IFNK))

Binding Specificity: AA 24-195

Reactivity: Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFNK antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Cow

Purification: >95%, Protein G purified

Immunogen: Recombinant Bovine Interferon tau-1 protein (24-195AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for IFNK

Target: IFNK (Interferon, kappa (IFNK))

Alternative Name: IFNT1 (IFNK Products)

Synonyms: IFNK antibody, IFNT1 antibody, INFE1 antibody, RP11-27J8.1 antibody, interferon kappa antibody, IFNK antibody, Ifnk antibody

Background:

Background: Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible.

Aliases: IFNT1 antibody, Interferon tau-1 antibody, IFN-tau-1 antibody, Antiluteolysin antibody, Trophoblast antiluteolytic protein antibody, Trophoblast protein 1 antibody, TP-1 antibody, Trophoblastin antibody

UniProt: P15696