RTN4RL2 antibody (AA 355-372) (HRP)

Catalog No. ABIN7140117

Product Details anti-RTN4RL2 Antibody (HRP)

Target: RTN4RL2 (Reticulon 4 Receptor-Like 2 (RTN4RL2))

Binding Specificity: AA 355-372

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RTN4RL2 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Peptide sequence from Human Reticulon-4 receptor-like 2 protein (355-372AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RTN4RL2

Target: RTN4RL2 (Reticulon 4 Receptor-Like 2 (RTN4RL2))

Alternative Name: RTN4RL2 (RTN4RL2 Products)

Background:

Background: Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis, protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed: 22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed: 22325200).

Aliases: RTN4RL2 antibody, NGRH1 antibody, NGRL3 antibody, Reticulon-4 receptor-like 2 antibody, Nogo receptor-like 3 antibody, Nogo-66 receptor homolog 1 antibody, Nogo-66 receptor-related protein 2 antibody, NgR2 antibody

UniProt: Q86UN3