OPRK1 antibody (AA 31-50)

Catalog No. ABIN7139899

Product Details anti-OPRK1 Antibody

Target: OPRK1 (Opioid Receptor, kappa 1 (OPRK1))

Binding Specificity: AA 31-50

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OPRK1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Peptide sequence from Human Kappa-type opioid receptor protein (31-50AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for OPRK1

Target: OPRK1 (Opioid Receptor, kappa 1 (OPRK1))

Alternative Name: OPRK1 (OPRK1 Products)

Synonyms: OPRK1 antibody, LOC780448 antibody, kor antibody, KOR antibody, OPRK antibody, K-OR-1 antibody, KOR-1 antibody, MSL-1 antibody, Oprk2 antibody, R21 antibody, opioid receptor, kappa 1 antibody, opioid receptor kappa 1 antibody, oprk1 antibody, OPRK1 antibody, Oprk1 antibody

Background:

Background: G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

Aliases: K-OR-1 antibody, Kappa opioid receptor antibody, Kappa type opioid receptor antibody, Kappa-type opioid receptor antibody, KOR 1 antibody, KOR antibody, KOR-1 antibody, Opiate receptor kappa 1 antibody, Opiate receptor, kappa 1 antibody, Opioid receptor, kappa 1 antibody, OPRK 1 antibody, OPRK antibody, OPRK_HUMAN antibody, OPRK1 antibody, Oprk2 antibody, R21 antibody

UniProt: P41145