IgG3 antibody (AA 312-324) (Biotin)

Catalog No. ABIN7139884

Product Details anti-IgG3 Antibody (Biotin)

Target: IgG3

Binding Specificity: AA 312-324

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IgG3 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Peptide sequence from Human Immunoglobulin heavy constant gamma 3 protein (312-324AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for IgG3

Target: IgG3

Alternative Name: IGHG3 (IgG3 Products)

Synonyms: IgG3 antibody, Immunoglobulin heavy constant gamma 3 antibody, immunoglobulin heavy constant gamma 3 (G3m marker) antibody, Ighg3 antibody, IGHG3 antibody

Target Type: Antibody

Background:

Background: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Aliases: IGHG3Immunoglobulin heavy constant gamma 3 antibody, HDC antibody, Heavy chain disease protein antibody, Ig gamma-3 chain C region antibody

UniProt: P01860