DAB2IP antibody (AA 85-100)

Catalog No. ABIN7139807

Product Details anti-DAB2IP Antibody

Target: DAB2IP (DAB2 Interacting Protein (DAB2IP))

Binding Specificity: AA 85-100

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DAB2IP antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Peptide sequence from Human Disabled homolog 2-interacting protein (85-100AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for DAB2IP

Target: DAB2IP (DAB2 Interacting Protein (DAB2IP))

Alternative Name: DAB2IP (DAB2IP Products)

Synonyms: dab2ip antibody, wu:fc08b07 antibody, wu:fk62h05 antibody, AF9Q34 antibody, AIP-1 antibody, AIP1 antibody, DIP1/2 antibody, 2310011D08Rik antibody, AI480459 antibody, Aip1 antibody, mKIAA1743 antibody, disabled homolog 2-interacting protein antibody, DAB2 interacting protein antibody, DAB2 interacting protein b antibody, disabled 2 interacting protein antibody, LOC100071680 antibody, DAB2IP antibody, dab2ipb antibody, dab2ip antibody, Dab2ip antibody

Background:

Background: Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Plays also a role in cell cycle checkpoint control, reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways, sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to proinflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway, specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5, recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on \'Ser-966\', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Mediates also TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6) and Ras. Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway, promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Functions also as a tumor suppressor protein in prostate cancer progression, prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively.

Aliases: DAB2IP antibody, AF9Q34 antibody, AIP1 antibody, KIAA1743Disabled homolog 2-interacting protein antibody, DAB2 interaction protein antibody, DAB2-interacting protein antibody, ASK-interacting protein 1 antibody, AIP-1 antibody, DOC-2/DAB-2 interactive protein antibody

UniProt: Q5VWQ8

Pathways: EGFR Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Tube Formation