Histone H3.3 antibody (2meLys79)

Catalog No. ABIN7139281

Product Details anti-Histone H3.3 Antibody

Target: Histone H3.3 (H3F3A) (H3 Histone, Family 3A (H3F3A))

Binding Specificity: 2meLys79

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Histone H3.3 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Peptide sequence around site of Di-methyl-Lys (79) derived from Human Histone H3.3

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:2000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Histone H3.3

Target: Histone H3.3 (H3F3A) (H3 Histone, Family 3A (H3F3A))

Alternative Name: H3F3A (H3F3A Products)

Background:

Background: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Aliases: H3 histone family 3A antibody, H3 histone family 3B antibody, H3 histone, family 3B (H3.3B) antibody, H3.3 antibody, H3.3A antibody, H3.3B antibody, H33_HUMAN antibody, H3F3 antibody, H3F3A antibody, H3f3b antibody, Histone H3.3 antibody, Histone H3.3Q antibody, Histone H3.A antibody, Histone H3.B antibody, MGC87782 antibody, MGC87783 antibody

UniProt: P84243