SHP1 antibody (pTyr536)

Catalog No. ABIN7139023

Product Details anti-SHP1 Antibody

Target: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Binding Specificity: pTyr536

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SHP1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of tyrosine 536 (S-E-Y(p)-G-N) derived from Human SHP-1.

Isotype: IgG

Application Details

Application Notes: IHC:1:50-1:100, IF:1:100-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SHP1

Target: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Alternative Name: PTPN6 (PTPN6 Products)

Synonyms: HCPH antibody, HPTP1C antibody, PTP-1C antibody, SH-PTP1 antibody, SHP-1 antibody, SHP-1L antibody, SHP1 antibody, DRPLA antibody, Hcph antibody, Ptp1C antibody, me antibody, motheaten antibody, Ptph6 antibody, Shp-1 antibody, fj22f05 antibody, wu:fj22f05 antibody, zgc:55501 antibody, ptpn6 antibody, protein tyrosine phosphatase, non-receptor type 6 antibody, protein tyrosine phosphatase, non-receptor type 6 L homeolog antibody, PTPN6 antibody, Ptpn6 antibody, ptpn6 antibody, ptpn6.L antibody

Background:

Background: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.

Migone TS, et al. (1998) Proc Natl Acad Sci USA, 95(7): 3845-3850.
Timms JF, et al.(1998) Mol Cell Biol, 18(7): 3838-3850.
Kanagasundaram V, et al. (1999) Mol Cell Biol, 19(6): 4079-4092.
Hauck CR, et al. (1999) Infect Immun, 67(10): 5490-5494.

Aliases: 70Z-SHP antibody, EC 3.1.3.48 antibody, HCP antibody, HCPH antibody, Hematopoietic cell phosphatase antibody, Hematopoietic cell protein tyrosine phosphatase antibody, Hematopoietic cell protein-tyrosine phosphatase antibody, HPTP1C antibody, Protein tyrosine phosphatase 1C antibody, Protein tyrosine phosphatase non receptor type 6 antibody, Protein tyrosine phosphatase SHP1 antibody, Protein-tyrosine phosphatase 1C antibody, protein-tyrosine phosphatase SHP 1 antibody, Protein-tyrosine phosphatase SHP-1 antibody, PTN6_HUMAN antibody, PTP 1C antibody, PTP-1C antibody, PTP1C antibody, Ptpn6 antibody, SH PTP 1 antibody, SH PTP1 antibody, SH-PTP1 antibody, SHP 1 antibody, SHP 1L antibody, SHP1 antibody, SHP1L antibody, tyrosine protein phosphatase non receptor type 6 antibody, Tyrosine-protein phosphatase non-receptor type 6 antibody

UniProt: P29350

Pathways: JAK-STAT Signaling, TCR Signaling, TLR Signaling, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, BCR Signaling