PIK3R1/PIK3R3 antibody (pTyr467)

Catalog No. ABIN7139011

Product Details anti-PIK3R1/PIK3R3 Antibody

Target: PIK3R1/PIK3R3 (PIK3R3A) (Phosphoinositide-3-Kinase, Regulatory Subunit 3a (Gamma) (PIK3R3A))

Binding Specificity: pTyr467

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIK3R1/PIK3R3 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Cross-Reactivity: Human, Mouse, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of tyrosine 467 (L-Y(p)-E-E-Y) derived from Human PI3 Kinase p85/p55.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:1000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PIK3R1/PIK3R3

Target: PIK3R1/PIK3R3 (PIK3R3A) (Phosphoinositide-3-Kinase, Regulatory Subunit 3a (Gamma) (PIK3R3A))

Alternative Name: PIK3R1/PIK3R3 (PIK3R3A Products)

Synonyms: wu:fb16a12 antibody, wu:fk56b03 antibody, zgc:73230 antibody, phosphoinositide-3-kinase, regulatory subunit 3a (gamma) antibody, pik3r3a antibody

Background:

Background:

Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1./Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.

Stoyanov, B. et al. (1995) Science 269, 690-3.
Simpson, L. and Parsons, R. (2001) Exp Cell Res 264, 29-41.
Neri, L.M. et al. (2002) Biochim Biophys Acta 1584, 73-80.

Aliases: p85, AGM7, p85-ALPHA, p55, p55-GAMMA

UniProt: P27986, Q92569