FRS2 antibody (pTyr436)

Catalog No. ABIN7139006

Product Details anti-FRS2 Antibody

Target: FRS2 (Fibroblast Growth Factor Receptor Substrate 2 (FRS2))

Binding Specificity: pTyr436

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FRS2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human, Mouse

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of tyrosine 436(L-N-Y(p)-I-Q) derived from Human FRS2 .

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:1000, IHC:1:50-1:100,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for FRS2

Target: FRS2 (Fibroblast Growth Factor Receptor Substrate 2 (FRS2))

Alternative Name: FRS2 (FRS2 Products)

Synonyms: frs2 antibody, wu:fd21h10 antibody, zgc:91973 antibody, FRS2A antibody, FRS2alpha antibody, SNT antibody, SNT-1 antibody, SNT1 antibody, 4732458E18 antibody, C330018A15Rik antibody, Frs2alpha antibody, fibroblast growth factor receptor substrate 2 antibody, fibroblast growth factor receptor substrate 2b antibody, FRS2 antibody, frs2b antibody, Frs2 antibody

Background:

Background:

FRS2 is an adaptor protein involved in fibroblast growth factor receptor (FGFR) signaling. Plays an important role in linking FGFR and nerve growth factor receptors with Ras/MAPK signaling pathways.

Xu H., J. Biol. Chem. 273:17987-17990(1998).
Meakin S.O., J. Biol. Chem. 274:9861-9870(1999).
Dhalluin C., Mol. Cell 6:921-929(2000).

Aliases: FGFR signaling adaptor SNT antibody, FGFR signalling adaptor antibody, FGFR substrate 2 antibody, FGFR-signaling adaptor SNT antibody, Fibroblast growth factor receptor substrate 2 antibody, FRS 2 antibody, FRS2 antibody, FRS2_HUMAN antibody, FRS2A antibody, FRS2alpha antibody, SNT 1 antibody, SNT antibody, SNT-1 antibody, SNT1 antibody, Suc 1 Associated Neurotrophic Factor Target antibody, Suc1 associated neurotrophic factor target 1 antibody, Suc1-associated neurotrophic factor target 1 antibody

UniProt: Q8WU20

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Signaling Events mediated by VEGFR1 and VEGFR2