beta Arrestin 1 antibody (pSer412)
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- Target See all beta Arrestin 1 (ARRB1) Antibodies
- beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))
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Binding Specificity
- pSer412
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This beta Arrestin 1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- Cross-Reactivity
- Human
- Purification
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
- Immunogen
- Peptide sequence around phosphorylation site of Serine 412 (T-G-S(p)-P-Q) derived from Human Arrestin 1.
- Isotype
- IgG
- Top Product
- Discover our top product ARRB1 Primary Antibody
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anti-Arrestin, beta 1 (ARRB1) (AA 3-246) antibody
ARRB1 Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Arrestin, beta 1 (ARRB1) (AA 169-418) antibodyARRB1 Reactivity: Human WB, IHC, IF, IP Host: Rabbit Polyclonal unconjugated
anti-Arrestin, beta 1 (ARRB1) (AA 336-363), (C-Term) antibodyARRB1 Reactivity: Human WB, IF, IHC (p), FACS Host: Rabbit Polyclonal RB31615 unconjugated
anti-Arrestin, beta 1 (ARRB1) antibodyARRB1 Reactivity: Human, Mouse, Rat WB, IHC, IF, IP, FACS, ICC Host: Rabbit Monoclonal unconjugated
anti-Arrestin, beta 1 (ARRB1) (AA 1-260) antibodyARRB1 Reactivity: Human WB, IHC, ELISA, IF Host: Rabbit Polyclonal unconjugated
anti-Arrestin, beta 1 (ARRB1) antibodyARRB1 Reactivity: Human, Mouse, Rat IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Arrestin, beta 1 (ARRB1) (AA 369-418) antibodyARRB1 Reactivity: Human WB, IHC, ELISA, IF, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Arrestin, beta 1 (ARRB1) (AA 343-371), (C-Term) antibodyARRB1 Reactivity: Human WB, IF, IHC (p), FACS, EIA Host: Rabbit Polyclonal unconjugated
anti-Arrestin, beta 1 (ARRB1) (Ser157) antibodyARRB1 Reactivity: Human, Monkey WB, IHC, ELISA, IF Host: Rabbit Polyclonal unconjugated
anti-Arrestin, beta 1 (ARRB1) (C-Term) antibodyARRB1 Reactivity: Human, Mouse, Rat WB, IHC, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB:1:500-1:1000, IHC:1:50-1:100,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))
- Alternative Name
- ARRB1 (ARRB1 Products)
- Background
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Background:
Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein, the binding appears to require additional receptor determinants exposed only in the active receptor conformation.
Greg Buchanan. AACR Meeting Abstracts, Apr 2006, 2006: 430.
D. Alex Groarke. Mol. Pharmacol., Feb 2001, 59: 375.
Karen McConalogue. Mol. Biol. Cell, Aug 1998, 9: 2305.
Maria Stella Lombardi. Stroke, Apr 2004, 35: 981 - 986.
Aliases: ARB1 antibody, ARR1 antibody, ARRB1 antibody, ARRB1_HUMAN antibody, Arrestin 2 antibody, Arrestin beta 1 antibody, Arrestin beta-1 antibody, Beta-arrestin-1 antibody
- UniProt
- P49407
- Pathways
- Positive Regulation of Peptide Hormone Secretion, Nuclear Hormone Receptor Binding, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
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