Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

PKM antibody (pSer37)

PKM Reactivity: Human ELISA, WB, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7138580
  • Target See all PKM Antibodies
    PKM (Pyruvate Kinase M1/2 (PKM))
    Binding Specificity
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer37
    Reactivity
    • 37
    • 11
    • 5
    Human
    Host
    • 34
    • 5
    Rabbit
    Clonality
    • 33
    • 6
    Polyclonal
    Conjugate
    • 22
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PKM antibody is un-conjugated
    Application
    • 24
    • 18
    • 12
    • 8
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunofluorescence (IF)
    Cross-Reactivity
    Human
    Purification
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
    Immunogen
    Peptide sequence around phosphorylation site of serine 37(I-D-S(p)-P-P) derived from Human PKM2.
    Isotype
    IgG
    Top Product
    Discover our top product PKM Primary Antibody
  • Application Notes
    WB:1:500-1:1000, IF:1:100-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    PKM (Pyruvate Kinase M1/2 (PKM))
    Alternative Name
    PKM (PKM Products)
    Background

    Background:

    Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.

    Aliases: PKM, PK3, OIP3, PK2

    Pathways
    Warburg Effect
You are here:
Support