TAL1 antibody (pSer122)

Catalog No. ABIN7138416

Product Details anti-TAL1 Antibody

Target: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Binding Specificity: pSer122

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAL1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Human, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of Serine 122(Q-L-S(p)-P-P) derived from Human TAL-1.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:1000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TAL1

Target: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Alternative Name: TAL1 (TAL1 Products)

Synonyms: SCL/tal-1 antibody, Scl antibody, bHLHa17 antibody, tal-1 antibody, SCL antibody, TCL5 antibody, scl antibody, tcl5 antibody, SCL-alpha antibody, SCL-beta antibody, scl/tal1 antibody, zgc:85605 antibody, T cell acute lymphocytic leukemia 1 antibody, TAL bHLH transcription factor 1, erythroid differentiation factor antibody, T-cell acute lymphocytic leukemia 1 S homeolog antibody, T-cell acute lymphocytic leukemia 1 antibody, Tal1 antibody, TAL1 antibody, tal1.S antibody, tal1 antibody

Background:

Background:

TAL-1 is a basic helix-loop-helix transcription. Regulates differentiation and survival during hemopoiesis. Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of eryhtroid differentiation. Mutations are associated with T-cell leukemia and melanoma. Binds to the LIM domain containing protein Rhombotin-2.

Aplan P.D., Mol. Cell. Biol. 10:6426-6435(1990).
Gregory S.G., Nature 441:315-321(2006).
Chen Q., J. Exp. Med. 172:1403-1408(1990).

Aliases: bHLHa17 antibody, Class A basic helix-loop-helix protein 17 antibody, OTTHUMP00000009563 antibody, OTTHUMP00000009564 antibody, SCL antibody, STEM CELL LEUKEMIA HEMATOPOIETIC TRANSCRIPTION FACTOR antibody, Stem cell protein antibody, T cell acute lymphocytic leukemia 1 antibody, T cell acute lymphocytic leukemia 1 protein antibody, T cell acute lymphocytic leukemia 1 protein antibody, T cell leukemia/lymphoma 5 protein antibody, T-cell acute lymphocytic leukemia protein 1 antibody, T-cell leukemia/lymphoma protein 5 antibody, Tal 1 antibody, Tal 1 product antibody, TAL 1 protein antibody, TAL bHLH transcription factor 1 erythroid differentiation factor antibody, TAL-1 antibody, tal1 antibody, TAL1_HUMAN antibody, TCL 5 antibody, TCL5 antibody

UniProt: P17542

Pathways: Stem Cell Maintenance