PRCP antibody

Catalog No. ABIN7130695

Product Details anti-PRCP Antibody

Target: PRCP (Prolylcarboxypeptidase (PRCP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRCP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human, Mouse

Purification: Antigen affinity purification

Immunogen: Fusion protein of Human PRCP

Isotype: IgG

Application Details

Application Notes: ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PRCP

Target: PRCP (Prolylcarboxypeptidase (PRCP))

Alternative Name: PRCP (PRCP Products)

Synonyms: OI13 antibody, PCOLC antibody, PCP antibody, PCP2 antibody, TLD antibody, humpcp antibody, MGC145178 antibody, 2510048K03Rik antibody, 2610104A14Rik antibody, AI451719 antibody, HUMPCP antibody, zgc:91816 antibody, bone morphogenetic protein 1 antibody, prolylcarboxypeptidase antibody, lysosomal Pro-X carboxypeptidase antibody, prolylcarboxypeptidase (angiotensinase C) antibody, BMP1 antibody, prcp antibody, LOC5579822 antibody, CpipJ_CPIJ006123 antibody, CpipJ_CPIJ006124 antibody, Prcp antibody, PRCP antibody

Background:

Background: The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH , but the enzyme activity is retained with some substrates at neutral pH . This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Aliases: Angiotensinase C antibody, HUMPCP antibody, Lysosomal carboxypeptidase C antibody, Lysosomal Pro X carboxypeptidase antibody, Lysosomal Pro-X carboxypeptidase antibody, MGC2202 antibody, PCP antibody, PCP_HUMAN antibody, PRCP antibody, Proline carboxypeptidase antibody, Prolylcarboxypeptidase (angiotensinase C) antibody, Prolylcarboxypeptidase antibody, prolylcarboxypeptidase isoform 1 preproprotein antibody

UniProt: P42785