IGSF6 antibody

Catalog No. ABIN7129823

Product Details anti-IGSF6 Antibody

Target: IGSF6 (Immunoglobulin Superfamily, Member 6 (IGSF6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IGSF6 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen affinity purification

Immunogen: Fusion protein of Human IGSF6

Isotype: IgG

Application Details

Application Notes: ELISA:1:1000-1:5000, IHC:1:5-1:20,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for IGSF6

Target: IGSF6 (Immunoglobulin Superfamily, Member 6 (IGSF6))

Alternative Name: IGSF6 (IGSF6 Products)

Synonyms: IGSF6 antibody, DORA antibody, immunoglobulin superfamily member 6 antibody, immunoglobulin superfamily, member 6 antibody, IGSF6 antibody, Igsf6 antibody

Background:

Background: IGSF6 (DORA), a novel member of the immunoglobulin superfamily (IGSF) from human and rat expressed in dendritic and myeloid cells. Using a probe from the open reading frame of the rat cDNA, we isolated a cosmid which contains the entire mouse gene. By comparative analysis and reverse transcriptase polymerase chain reaction, we defined the intron/exon structure and the mRNA of the mouse gene and, with respect to human BAC clones, the human gene. The genes span 10 kb (mouse) and 12 kb (human), with six exons arranged in a manner similar to other members of the IGSF. All intron/exon boundaries follow the GT-AG rule. Expression of the mouse Igsf6 gene is restricted to cells of the immune system, particularly macrophages. Northern blot revealed a single mRNA of 2.5 kb, in contrast to the human gene which is expressed as two mRNAs of 1 and 2.5 kb. The human and mouse genes were localized to a locus associated with inflammatory bowel disease. Analysis of the flanking regions of the Igsf6 gene revealed the presence of an unrelated gene, transcribed from the opposite strand of the DNA and oriented such that the Igsf6 gene is encoded entirely within an intron. An identical organization is seen in human.

Aliases: Donwregulated by activation gene antibody, DORA antibody, Down regulated by activation (immunoglobulin superfamily) antibody, IgSF6 antibody, IGSF6_HUMAN antibody, Immunoglobulin superfamily member 6 antibody, Protein DORA antibody

UniProt: O95976