CYFIP2 antibody

Catalog No. ABIN7129118

Product Details anti-CYFIP2 Antibody

Target: CYFIP2 (Cytoplasmic FMR1 Interacting Protein 2 (CYFIP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYFIP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human, Mouse

Purification: Antigen affinity purification

Immunogen: Fusion protein of Human CYFIP2

Isotype: IgG

Application Details

Application Notes: ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CYFIP2

Target: CYFIP2 (Cytoplasmic FMR1 Interacting Protein 2 (CYFIP2))

Alternative Name: CYFIP2 (CYFIP2 Products)

Synonyms: CYFIP2 antibody, pir121 antibody, PIR121 antibody, zgc:194528 antibody, 1500004I01Rik antibody, 6430511D02Rik antibody, AA930218 antibody, AU022376 antibody, Pir121 antibody, mKIAA1168 antibody, cytoplasmic FMR1 interacting protein 2 antibody, CYFIP2 antibody, cyfip2 antibody, Cyfip2 antibody

Background:

Background: CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1,278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation.

Aliases: CYFIP2 antibody, KIAA1168 antibody, PIR121Cytoplasmic FMR1-interacting protein 2 antibody, p53-inducible protein 121 antibody

UniProt: Q96F07

Pathways: RTK Signaling, Apoptosis, Positive Regulation of Endopeptidase Activity