ADD2 antibody

Catalog No. ABIN7128257

Product Details anti-ADD2 Antibody

Target: ADD2 (Adducin 2 (Beta) (ADD2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADD2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen affinity purification

Immunogen: Fusion protein of Human ADD2

Isotype: IgG

Application Details

Application Notes: ELISA:1:1000-1:2000, IHC:1:15-1:50,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ADD2

Target: ADD2 (Adducin 2 (Beta) (ADD2))

Alternative Name: ADD2 (ADD2 Products)

Synonyms: si:dkey-202n14.5 antibody, ADDB antibody, 2900072M03Rik antibody, add97 antibody, beta-ADD antibody, adducin 2 antibody, adducin 2 (beta) antibody, ADD2 antibody, add2 antibody, Add2 antibody

Background:

Background: Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described.

Aliases: ADD 2 antibody, ADD2 antibody, ADDB antibody, ADDB_HUMAN antibody, Adducin 2 (beta) antibody, Adducin2 antibody, Beta adducin antibody, Beta-adducin antibody, Erythrocyte adducin subunit beta antibody, OTTHUMP00000203378 antibody, OTTHUMP00000203908 antibody

UniProt: P35612

Pathways: Regulation of Actin Filament Polymerization