Recombinant TXN antibody

Catalog No. ABIN7127856

Product Details anti-TXN Antibody

Target: TXN (Thioredoxin (TXN))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TXN antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Human, Rat

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human TRX1

Clone: 3G7

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TXN

Target: TXN (Thioredoxin (TXN))

Alternative Name: TXN (TXN Products)

Background:

Background: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.

Aliases: Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP), TXN, TRDX TRX TRX1

UniProt: P10599

Pathways: Carbohydrate Homeostasis, Cell RedoxHomeostasis