GTF2IRD2 antibody

Catalog No. ABIN7127094

Product Details anti-GTF2IRD2 Antibody

Target: GTF2IRD2 (GTF2I Repeat Domain Containing 2 (GTF2IRD2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GTF2IRD2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Specificity: The TFII-I family contains two highly homologous 949 amino acid proteins, GTF2IRD2 (GTF2I repeat domain containing 2) and GTF2IRD2B (general transcription factor II-I repeat domain-containing protein 2B). Localizing to the nucleus, these proteins are ubiquitously expressed and contain two GTF2I- like repeats. Encoded by a gene mapping to human chromosome 7q11.23, GTF2IRD2 and GTF2IRD2B are located in the Williams-Beuren syndrome (WBS) critical region. The deletion of genes located within this region results in WBS, possibly due to the unequal crossing over of highly homologous low-copy repeat sequences that flank the deleted region. WBS is an autosomal dominant genetic condition that is characterized by physical, cognitive and behavioral traits including facial dysmorphology, vascular stenoses, growth deficiencies, dental anomalies and neurologic and musculoskeletal abnormalities.

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant full-length human GTF2IRD2 protein

Isotype: IgG2b

Application Details

Application Notes:

Known_Application: Flow Cytometry (1-2 μg/million cells), Western Blot (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

Positive_Control: HeLa or K562 cells.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for GTF2IRD2

Target: GTF2IRD2 (GTF2I Repeat Domain Containing 2 (GTF2IRD2))

Alternative Name: GTF2IRD2 (GTF2IRD2 Products)

Synonyms: FP630 antibody, GTF2IRD2 alpha antibody, GTF2IRD2A antibody, 1700012P16Rik antibody, GTF2I repeat domain containing 2 antibody, GTF2IRD2 antibody, Gtf2ird2 antibody

Background: FP630, GTF2IRD2A, GTF2IRD2 alpha,GTF2IRD2
Cellular localisation: Nucleus.

Molecular Weight: 107kDa

Gene ID: 84163, 647039

UniProt: Q86UP8