NOC4L antibody

Catalog No. ABIN7127072

Product Details anti-NOC4L Antibody

Target: NOC4L (Nucleolar Complex Associated 4 Homolog (NOC4L))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NOC4L antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Specificity: Treg activation is critical for maintaining self-tolerance, but the translational control of this process is still poorly understood. Zhu et al. report a conserved ribosome biogenesis factor, Noc4L, that regulates mRNAs related to Treg and Tconv activation but does not affect global protein translation. Noc4L regulates translation of mRNAs related to Treg activation. Noc4L plays critical roles in activation of Tregs and Tconvs. Noc4L-mediated ribosome biogenesis is critical in controlling the activation of Tregs and maintaining immune tolerance. [Zhu et al., 2019, Cell Reports 27, 1205 1220.]

Cross-Reactivity (Details): Human

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant full-length human NOC4L protein

Isotype: IgG1

Application Details

Application Notes:

Known_Application: Flow Cytometry (1-2 μg/million cells), ,Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

Positive_Control: HeLa or 293T cells.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for NOC4L

Target: NOC4L (Nucleolar Complex Associated 4 Homolog (NOC4L))

Alternative Name: NOC4L (NOC4L Products)

Background: NOC4 protein homolog, NOC4-like protein, Nucleolar complex protein 4 homolog, Nucleolar complex-associated protein 4-like protein,Nucleolar complex-associated protein 4-like protein (NOC4L)
Cellular localisation: Nucleus.

Molecular Weight: 58.4kDa

Gene ID: 79050, 558536

UniProt: Q9BVI4