Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

CDX1 antibody

CDX1 Reactivity: Human IHC (f) Host: Mouse Monoclonal unconjugated
Catalog No. ABIN7504134
  • Target See all CDX1 Antibodies
    CDX1 (Caudal Type Homeobox 1 (CDX1))
    Reactivity
    • 59
    • 27
    • 20
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Human
    Host
    • 53
    • 7
    Mouse
    Clonality
    • 44
    • 16
    Monoclonal
    Conjugate
    • 26
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CDX1 antibody is un-conjugated
    Application
    • 40
    • 15
    • 13
    • 8
    • 7
    • 4
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Specificity
    The members of the murine Cdx family (Cdx1, Cdx2, and Cdx4) are members of the caudal-type homeobox family of genes, which are homologues of the Drosophila caudal gene required for anterior-posterior regional identity. The intestine-specific transcription factors Cdx1 and Cdx2 are candidate genes for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. The relative expression of Cdx1 to Cdx2 protein may be important in the anterior to posterior patterning of the intestinal epithelium and in defining patterns of proliferation and differentiation along the crypt-villus axis. Expression of the Cdx1 homeobox gene in epithelial intestinal cells promotes cellular growth and differentiation. Cdx1 positively regulates its own expression. Cdx1 and Cdx2 are expressed in the small intestine and colon of fetus and adult. A decrease in human Cdx1 and/or Cdx2 expression is associated with colorectal tumorigenesis. Both Cdx1 and Cdx2 genes must be expressed to reduce tumorigenic potential, to increase sensitivity to apoptosis and to reduce cell migration, suggesting that the two genes control the normal phenotype by independent pathways. The human Cdx1 gene maps to chromosome 5q32 and encodes a 265-amino acid protein.
    Cross-Reactivity (Details)
    Human.
    Purification
    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
    Immunogen
    Recombinant human full-length CDX1 protein
    Isotype
    IgG1
    Top Product
    Discover our top product CDX1 Primary Antibody
  • Application Notes

    Positive Control: HT29 cells. Colon Carcinoma

    Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    Prepared in 10 mM PBS with 0.05 % BSA and 0.05 % azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-80 °C
    Storage Comment
    Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. Non-hazardous. Also available WITHOUT BSA & azide at 1.0mg/ml.
    Expiry Date
    24 months
  • Target
    CDX1 (Caudal Type Homeobox 1 (CDX1))
    Alternative Name
    CDX1 (CDX1 Products)
    Synonyms
    Cdx antibody, Cdx-1 antibody, cdx-1 antibody, xcad2 antibody, xtcad2 antibody, CDX-A antibody, CDXA antibody, CHOX-CAD1 antibody, CHox-cad antibody, CDX1 antibody, xCAD2 antibody, zgc:165581 antibody, cdx2 antibody, caudal type homeobox 1 antibody, caudal type homeo box 1 antibody, caudal type homeobox 1 S homeolog antibody, caudal type homeobox 1 b antibody, caudal type homeobox 1a antibody, CDX1 antibody, Cdx1 antibody, cdx1 antibody, cdx1.S antibody, cdx1b antibody, cdx1a antibody
    Background
    Caudal type homeobox 1, Caudal type homeobox transcription factor 1, Caudal-type homeobox protein 1,CDX1,CDX1 / Caudal Type Homeobox 1 (Intestine-Specific Transcription Factor)
    Cellular localisation: Nuclear
    Molecular Weight
    28kDa
    Gene ID
    1044, 1545
    UniProt
    P47902
You are here:
Support