WDR24 antibody

Catalog No. ABIN7120816

Product Details anti-WDR24 Antibody

Target: WDR24 (WD Repeat Domain 24 (WDR24))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WDR24 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: WD repeat domain 24

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:5000, IP: 1:200-1:2000, IF: 1:10-1:100, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for WDR24

Target: WDR24 (WD Repeat Domain 24 (WDR24))

Alternative Name: WDR24 (WDR24 Products)

Synonyms: C16orf21 antibody, JFP7 antibody, BC037651 antibody, wu:fd05f12 antibody, zgc:55946 antibody, WD repeat domain 24 antibody, WD repeat domain 24 L homeolog antibody, WDR24 antibody, Wdr24 antibody, wdr24 antibody, wdr24.L antibody

Background: Synonyms:C16orf21, DKFZp434F054, JFP7, WD repeat domain 24, WDR24 Background:As a component of the GATOR subcomplex GATOR2, functions as an activator of the amino acid-sensing branch of the TORC1 pathway(PubMed:23723238, PubMed:27166823). Inhibits the GATOR1 subcomplex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway(PubMed:23723238). Functions downstream of and is regulated by amino acid sensors like SESN2(PubMed:26449471, PubMed:26586190). In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux(PubMed:27166823).

Molecular Weight: 102 kDa

Gene ID: 84219

UniProt: Q96S15