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VPS26A antibody

VPS26A Reactivity: Human, Rat, Mouse WB, ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7120721
  • Target See all VPS26A Antibodies
    VPS26A (Vacuolar Protein Sorting-Associated Protein 26A (VPS26A))
    Reactivity
    • 41
    • 15
    • 15
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Rat, Mouse
    Host
    • 40
    • 1
    • 1
    Rabbit
    Clonality
    • 33
    • 9
    Polyclonal
    Conjugate
    • 19
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This VPS26A antibody is un-conjugated
    Application
    • 23
    • 15
    • 7
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    Purification
    Immunogen affinity purified
    Purity
    ≥95 % as determined by SDS-PAGE
    Immunogen
    vacuolar protein sorting 26 homolog A
    Isotype
    IgG
    Top Product
    Discover our top product VPS26A Primary Antibody
  • Application Notes
    WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Expiry Date
    12 months
  • Target
    VPS26A (Vacuolar Protein Sorting-Associated Protein 26A (VPS26A))
    Alternative Name
    VPS26A (VPS26A Products)
    Synonyms
    HB58 antibody, Hbeta58 antibody, PEP8A antibody, VPS26 antibody, AA407240 antibody, Vps26 antibody, VPS26A antibody, MNC6.7 antibody, MNC6_7 antibody, vacuolar protein sorting 26A antibody, DKFZp459G2011 antibody, hb58 antibody, hbeta58 antibody, pep8a antibody, vps26 antibody, vps26a antibody, wu:fc67e06 antibody, zgc:56673 antibody, VPS26, retromer complex component A antibody, VPS26 retromer complex component A antibody, vacuolar protein sorting 26A antibody, vacuolar protein sorting 26 antibody, vacuolar protein sorting homolog26 antibody, vacuolar protein sorting 26 homolog A (S. pombe) pseudogene antibody, VPS26 retromer complex component A S homeolog antibody, VPS26 retromer complex component A L homeolog antibody, vacuolar protein sorting 26 homolog A (S. pombe) antibody, VPS26A antibody, Vps26a antibody, LOC692917 antibody, vpsh26 antibody, LOC100147400 antibody, vps26a.S antibody, vps26a.L antibody, vps26a antibody
    Background
    Synonyms:FLJ12930, HB58, Hbeta58, hVPS26, PEP8A, Vesicle protein sorting 26A, VPS26, VPS26A Background:Acts as component of the retromer cargo-selective complex(CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network(TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins(Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5(Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R(PubMed:15078902, PubMed:15078903). Required to regulate transcytosis of the polymeric immunoglobulin receptor(pIgR-pIgA)(PubMed:15247922). Required for the endosomal localization of FAM21A(indicative for the WASH complex)(PubMed:22070227). Required for the endosomal localization of TBC1D5(PubMed:20923837). Mediates retromer cargo reognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP(PubMed:22279231). Involved in retromer-independent lysosomal sorting of F2R(PubMed:16407403). Involved in recycling of ADRB2(PubMed:21602791). Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins(By similarity).
    Molecular Weight
    38 kDa
    Gene ID
    9559
    UniProt
    O75436
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