VPS41 antibody

Catalog No. ABIN7120712

Product Details anti-VPS41 Antibody

Target: VPS41 (Vacuolar Protein Sorting 41 Homolog (VPS41))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VPS41 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: vacuolar protein sorting 41 homolog(S. cerevisiae)

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:1000, IF: 1:10-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for VPS41

Target: VPS41 (Vacuolar Protein Sorting 41 Homolog (VPS41))

Alternative Name: VPS41 (VPS41 Products)

Synonyms: AI317346 antibody, Vam2 antibody, mVam2 antibody, HVPS41 antibody, HVSP41 antibody, hVps41p antibody, RGD1560511 antibody, ATVAM2 antibody, ATVPS41 antibody, T23G18.5 antibody, T23G18_5 antibody, VACUOLAR PROTEIN SORTING 41 antibody, VAM2 antibody, ZIGZAG SUPPRESSOR 2 antibody, ZIP2 antibody, vacuolar protein sorting 41 antibody, Vacuolar assembly protein VPS41 homolog antibody, VPS41, HOPS complex subunit antibody, vacuolar protein sorting 41 antibody, vacuolar protein sorting 41, putative antibody, Vacuolar protein sorting-associated protein 41 homolog antibody, VPS41 HOPS complex subunit antibody, Bm1_34430 antibody, VPS41 antibody, CNI02550 antibody, CC1G_08871 antibody, MCYG_00680 antibody, VDBG_03430 antibody, MGYG_01292 antibody, CGB_H3560C antibody, vps-41 antibody, Vps41 antibody

Background: Synonyms:HVPS41, hVps41p, HVSP41, S53, VPS41 Background:Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes(PubMed:23351085). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo(PubMed:9159129, PubMed:23167963, PubMed:25445562, PubMed:25908847). Required for fusion of autophagosomes with lysosomes(PubMed:25783203). May link the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion(PubMed:25445562, PubMed:25908847). Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS(PubMed:23322049). Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adaptor complex(By similarity). May play a role in HOPS-independent function in the regulated secretory pathway(PubMed:24210660).

Molecular Weight: 70 kDa, 93 kDa

Gene ID: 27072

UniProt: P49754