Spt6 antibody
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- Target See all Spt6 (SUPT6H) Antibodies
- Spt6 (SUPT6H) (Suppressor of Ty 6 Homolog (SUPT6H))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Spt6 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunoprecipitation (IP)
- Purification
- Immunogen affinity purified
- Purity
- ≥95 % as determined by SDS-PAGE
- Immunogen
- suppressor of Ty 6 homolog(S. cerevisiae)
- Isotype
- IgG
- Top Product
- Discover our top product SUPT6H Primary Antibody
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- Application Notes
- WB: 1:500-1:2000, IP: 1:200-1:2000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- Expiry Date
- 12 months
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- Target
- Spt6 (SUPT6H) (Suppressor of Ty 6 Homolog (SUPT6H))
- Alternative Name
- SUPT6H (SUPT6H Products)
- Synonyms
- SPT6 antibody, SPT6H antibody, emb-5 antibody, 5131400N11Rik antibody, AI132449 antibody, Supt6h antibody, mKIAA0162 antibody, Spt6 antibody, wu:fj42h11 antibody, SUPT6H antibody, spt6 antibody, spt6h antibody, MGC146884 antibody, SPT6 homolog, histone chaperone antibody, suppressor of Ty 6 antibody, SUPT6H,-like protein to suppressor of ty 6 antibody, transcription elongation factor SPT6 antibody, suppressor of Ty 6 homolog (S. cerevisiae) antibody, chromatin-remodeling histone chaperone antibody, SUPT6H antibody, Supt6 antibody, Supt6h antibody, supt6h antibody, LOC100092175 antibody, SPT6 antibody
- Background
- Synonyms:KIAA0162, SPT6H Background:Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II(RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain(CTD) of the RNAPII subunit RPB1(POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors(ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes(such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase(AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A.
- Molecular Weight
- 230 kDa
- Gene ID
- 9913
- UniProt
- Q7KZ85
- Pathways
- Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Production of Molecular Mediator of Immune Response
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