Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

SETMAR antibody

SETMAR Reactivity: Human WB, ELISA, IP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7118987
  • Target See all SETMAR Antibodies
    SETMAR (SET Domain and Mariner Transposase Fusion Gene (SETMAR))
    Reactivity
    • 20
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 17
    • 2
    • 1
    Rabbit
    Clonality
    • 20
    Polyclonal
    Conjugate
    • 13
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SETMAR antibody is un-conjugated
    Application
    • 8
    • 4
    • 4
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunoprecipitation (IP)
    Purification
    Immunogen affinity purified
    Purity
    ≥95 % as determined by SDS-PAGE
    Immunogen
    SET domain and mariner transposase fusion gene
    Isotype
    IgG
    Top Product
    Discover our top product SETMAR Primary Antibody
  • Application Notes
    WB: 1:500-1:2000, IP: 1:200-1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Expiry Date
    12 months
  • Target
    SETMAR (SET Domain and Mariner Transposase Fusion Gene (SETMAR))
    Alternative Name
    SETMAR (SETMAR Products)
    Synonyms
    HsMar1 antibody, METNASE antibody, Mar1 antibody, 5830404F24Rik antibody, Etet2 antibody, SETMAR antibody, zgc:172212 antibody, SET domain and mariner transposase fusion gene antibody, SET domain without mariner transposase fusion antibody, histone-lysine N-methyltransferase SETMAR antibody, SETMAR antibody, Setmar antibody, LOC470738 antibody, setmar antibody, LOC703880 antibody, LOC100447656 antibody, LOC100586616 antibody
    Background
    Synonyms: Background:Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats(TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity(PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining(PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A(PubMed:18790802, PubMed:20457750).
    Molecular Weight
    77 kDa
    Gene ID
    6419
    UniProt
    Q53H47
    Pathways
    Positive Regulation of Response to DNA Damage Stimulus
You are here:
Support