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RNPS1 antibody

RNPS1 Reactivity: Human, Mouse, Rat WB, ELISA, IP, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7118717
  • Target See all RNPS1 Antibodies
    RNPS1 (RNA-Binding Protein S1 (RNPS1))
    Reactivity
    Human, Mouse, Rat
    Host
    • 3
    • 3
    Rabbit
    Clonality
    • 4
    • 2
    Polyclonal
    Conjugate
    • 6
    This RNPS1 antibody is un-conjugated
    Application
    Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)
    Purification
    Immunogen affinity purified
    Purity
    ≥95 % as determined by SDS-PAGE
    Immunogen
    RNA binding protein S1, serine-rich domain
    Isotype
    IgG
    Top Product
    Discover our top product RNPS1 Primary Antibody
  • Application Notes
    WB: 1:500-1:2000, IP: 1:200-1:1000, IF: 1:20-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Expiry Date
    12 months
  • Target
    RNPS1 (RNA-Binding Protein S1 (RNPS1))
    Alternative Name
    RNPS1 (RNPS1 Products)
    Synonyms
    E5.1 antibody, ribonucleic acid binding protein S1 antibody, RNA binding protein with serine rich domain 1 antibody, RNA binding protein S1, serine-rich domain antibody, Rnps1 antibody, RNPS1 antibody
    Background
    Synonyms:LDC2 Background:Part of pre-and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex(EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X(and probably other apoptotic genes), specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S), the activity is different from the established EJC assembly and function. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay(NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions.
    Molecular Weight
    55-60 kDa
    Gene ID
    10921
    UniProt
    Q15287
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