CTR9 antibody

Catalog No. ABIN7118709

Product Details anti-CTR9 Antibody

Target: CTR9 (RNA Polymerase-Associated Protein CTR9 Homolog (CTR9))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTR9 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: Ctr9, Paf1/RNA polymerase II complex component, homolog(S. cerevisiae)

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for CTR9

Target: CTR9 (RNA Polymerase-Associated Protein CTR9 Homolog (CTR9))

Alternative Name: CTR9 (CTR9 Products)

Synonyms: SH2BP1 antibody, TSBP antibody, p150 antibody, p150TSP antibody, AA409336 antibody, Sh2bp1 antibody, Tsbp antibody, Tsp antibody, mKIAA0155 antibody, sh2bp1 antibody, p150tsp antibody, tsbp antibody, fc54a06 antibody, wu:fc54a06 antibody, CTR9 homolog, Paf1/RNA polymerase II complex component antibody, CTR9 homolog, Paf1/RNA polymerase II complex component S homeolog antibody, Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) antibody, RNA polymerase-associated protein CTR9 homolog antibody, CTR9 antibody, Ctr9 antibody, ctr9.S antibody, ctr9 antibody, LOC100161197 antibody, LOC100163982 antibody, LOC100168634 antibody, LOC100478349 antibody, LOC100543206 antibody, LOC100645071 antibody

Background: Synonyms:KIAA0155, SH2BP1 Background:Component of the PAF1 complex(PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'-and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1, it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4'(H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B(H2BK120ub1), UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono-and trimethylation on histone H3 'Lys-4'(H3K4me3) and dimethylation on histone H3 'Lys-79'(H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 'Lys-4'(H3K4me3) on genes involved in stem cell pluripotency, this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway, may regulate DNA-association of STAT3(By similarity).

Molecular Weight: 130-150kd

Gene ID: 9646

UniProt: Q6PD62

Pathways: Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance