RBM25 antibody

Catalog No. ABIN7118681

Product Details anti-RBM25 Antibody

Target: RBM25 (RNA Binding Motif Protein 25 (RBM25))

Reactivity: Mouse, Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RBM25 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: RNA binding motif protein 25

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:2000, IP: 1:200-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for RBM25

Target: RBM25 (RNA Binding Motif Protein 25 (RBM25))

Alternative Name: RBM25 (RBM25 Products)

Synonyms: fi03e10 antibody, zgc:56208 antibody, wu:fi03e10 antibody, si:ch211-105d18.5 antibody, rnpc7 antibody, s164 antibody, NET52 antibody, RED120 antibody, RNPC7 antibody, S164 antibody, Snu71 antibody, fSAP94 antibody, 2600011C06Rik antibody, 2610015J01Rik antibody, A130095G20Rik antibody, AI159652 antibody, AL023075 antibody, AU043498 antibody, RNA binding motif protein 25b antibody, RNA binding motif protein 25 antibody, RNA binding motif protein 25 S homeolog antibody, putative rna binding motif protein 25 antibody, rbm25b antibody, Rbm25 antibody, rbm25.S antibody, rbm25 antibody, RBM25 antibody, Smp_078610 antibody

Background: Synonyms:fSAP94, NET52, Protein S164, RBM25, RED120, RNA binding motif protein 25, RNA binding protein 25, RNPC7, S164 Background:RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site(5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure.

Molecular Weight: 110-120 kDa

Gene ID: 58517

UniProt: P49756