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RNF4 antibody

RNF4 Reactivity: Human, Mouse, Rat ELISA, IP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7118657
  • Target See all RNF4 Antibodies
    RNF4 (Ring Finger Protein 4 (RNF4))
    Reactivity
    Human, Mouse, Rat
    Host
    • 17
    • 2
    Rabbit
    Clonality
    • 18
    • 1
    Polyclonal
    Conjugate
    • 12
    • 3
    • 2
    • 2
    This RNF4 antibody is un-conjugated
    Application
    • 10
    • 9
    • 4
    • 2
    • 1
    • 1
    ELISA, Immunoprecipitation (IP)
    Purification
    Immunogen affinity purified
    Purity
    ≥95 % as determined by SDS-PAGE
    Immunogen
    ring finger protein 4
    Isotype
    IgG
    Top Product
    Discover our top product RNF4 Primary Antibody
  • Application Notes
    IP: 1:200-1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Expiry Date
    12 months
  • Target
    RNF4 (Ring Finger Protein 4 (RNF4))
    Alternative Name
    RNF4 (RNF4 Products)
    Synonyms
    SLX5 antibody, SNURF antibody, AU018689 antibody, Gtrgeo8 antibody, ring finger protein 4 antibody, RNF4 antibody, Rnf4 antibody
    Background
    Synonyms:SNURF Background:E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'-and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.
    Gene ID
    6047
    UniProt
    P78317
    Pathways
    Intracellular Steroid Hormone Receptor Signaling Pathway
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