RNF4 antibody

Catalog No. ABIN7118657

Product Details anti-RNF4 Antibody

Target: RNF4 (Ring Finger Protein 4 (RNF4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF4 antibody is un-conjugated

Application: ELISA, Immunoprecipitation (IP)

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: ring finger protein 4

Isotype: IgG

Application Details

Application Notes: IP: 1:200-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for RNF4

Target: RNF4 (Ring Finger Protein 4 (RNF4))

Alternative Name: RNF4 (RNF4 Products)

Synonyms: SLX5 antibody, SNURF antibody, AU018689 antibody, Gtrgeo8 antibody, ring finger protein 4 antibody, RNF4 antibody, Rnf4 antibody

Background: Synonyms:SNURF Background:E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'-and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.

Gene ID: 6047

UniProt: P78317

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway