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RNF20 antibody

RNF20 Reactivity: Human, Mouse, Rat WB, ELISA, IF, IP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7118646
  • Target See all RNF20 Antibodies
    RNF20 (Ring Finger Protein 20 (RNF20))
    Reactivity
    • 63
    • 34
    • 20
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Human, Mouse, Rat
    Host
    • 57
    • 6
    Rabbit
    Clonality
    • 50
    • 13
    Polyclonal
    Conjugate
    • 28
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RNF20 antibody is un-conjugated
    Application
    • 43
    • 17
    • 13
    • 7
    • 7
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)
    Purification
    Immunogen affinity purified
    Purity
    ≥95 % as determined by SDS-PAGE
    Immunogen
    ring finger protein 20
    Isotype
    IgG
    Top Product
    Discover our top product RNF20 Primary Antibody
  • Application Notes
    WB: 1:500-1:2000, IP: 1:200-1:1000, IF: 1:20-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Expiry Date
    12 months
  • Target
    RNF20 (Ring Finger Protein 20 (RNF20))
    Alternative Name
    RNF20 (RNF20 Products)
    Background
    Synonyms:BRE1A Background:Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B(H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation(H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B, reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation.
    Molecular Weight
    114 kDa
    Gene ID
    56254
    UniProt
    Q5VTR2
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