MPS-1 antibody, MPS1 antibody, S27 antibody, 3200001M24Rik antibody, GB13072 antibody, DDBDRAFT_0203425 antibody, DDBDRAFT_0231065 antibody, DDB_0203425 antibody, DDB_0231065 antibody, mps-1 antibody, mps1 antibody, ribosomal protein S27 antibody, 40S ribosomal protein S27 antibody, ribosomal protein S27 pseudogene antibody, Ribosomal protein S27, component of cytosolic 80S ribosome and 40S small subunit antibody, component of 80S ribosome and 40S small subunit antibody, ribosomal protein S27 L homeolog antibody, RPS27 antibody, Rps27 antibody, LOC726295 antibody, RPS27P antibody, rps27 antibody, rps27.L antibody, rps-27 antibody
Background
Synonyms:MPS1 Background:Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the S27e family of ribosomal proteins and component of the 40S subunit. The encoded protein contains a C4-type zinc finger domain that can bind to zinc and may bind to nucleic acid. Studies in rat indicate that ribosomal protein S27 is located near ribosomal protein S18 in the 40S subunit and is covalently linked to translation initiation factor eIF3. Mutations in this gene have been identified in numerous melanoma patients and in at least one patient with Diamond-Blackfan anemia (DBA). Elevated expression of this gene has been observed in various human cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.