ARHGEF18 antibody

Catalog No. ABIN7118503

Product Details anti-ARHGEF18 Antibody

Target: ARHGEF18 (rho/rac Guanine Nucleotide Exchange Factor (GEF) 18 (ARHGEF18))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARHGEF18 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: rho/rac guanine nucleotide exchange factor(GEF) 18

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for ARHGEF18

Target: ARHGEF18 (rho/rac Guanine Nucleotide Exchange Factor (GEF) 18 (ARHGEF18))

Alternative Name: ARHGEF18 (ARHGEF18 Products)

Synonyms: arhgef18 antibody, wu:fc21e04 antibody, wu:fj05f11 antibody, zgc:85686 antibody, P114-RhoGEF antibody, AI467246 antibody, D030053O22Rik antibody, rho/rac guanine nucleotide exchange factor (GEF) 18a antibody, Rho/Rac guanine nucleotide exchange factor (GEF) 18 antibody, Rho/Rac guanine nucleotide exchange factor 18 antibody, rho guanine nucleotide exchange factor 18 antibody, rho/rac guanine nucleotide exchange factor (GEF) 18 antibody, arhgef18a antibody, ARHGEF18 antibody, LOC100027283 antibody, Arhgef18 antibody

Background: Synonyms:KIAA0521 Background:Acts as guanine nucleotide exchange factor(GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species(ROS). Does not act as a GEF for CDC42. The G protein beta-gamma(Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells(PubMed:22006950).

Molecular Weight: 120-130 kDa

Gene ID: 23370

UniProt: Q6ZSZ5

Pathways: Neurotrophin Signaling Pathway