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ARHGEF4 antibody
ARHGEF4
Reactivity: Human, Mouse
WB, ELISA, IHC
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-ARHGEF4 Antibody
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Target
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ARHGEF4
(rho Guanine Nucleotide Exchange Factor (GEF) 4 (ARHGEF4))
Reactivity
All reactivities for ARHGEF4 antibodies
Human, Mouse
Host
All hosts for ARHGEF4 antibodies
Rabbit
Clonality
All clonalities for ARHGEF4 antibodies
Polyclonal
Conjugate
All conjugates for ARHGEF4 antibodies
This ARHGEF4 antibody is un-conjugated
Application
Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
Purification
Immunogen affinity purified
Purity
≥95 % as determined by SDS-PAGE
Immunogen
Rho guanine nucleotide exchange factor(GEF) 4
Isotype
IgG
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Discover our top product ARHGEF4 Primary Antibody
Alternatives
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Application Details
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Application Notes
WB: 1:500-1:2000, IHC: 1:20-1:200
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
-20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Expiry Date
12 months
Target Details for ARHGEF4
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Target
ARHGEF4
(rho Guanine Nucleotide Exchange Factor (GEF) 4 (ARHGEF4))
Alternative Name
ARHGEF4 (ARHGEF4 Products )
Synonyms
ARHGEF4 antibody, ASEF antibody, ASEF1 antibody, GEF4 antibody, STM6 antibody, 9330140K16Rik antibody, Asef antibody, ENSMUSG00000070955 antibody, Rho guanine nucleotide exchange factor 4 antibody, uncharacterized LOC100470646 antibody, rho guanine nucleotide exchange factor 4 antibody, Rho guanine nucleotide exchange factor (GEF) 4 antibody, ARHGEF4 antibody, arhg4 antibody, LOC100470646 antibody, LOC100544917 antibody, Arhgef4 antibody
Background
Synonyms:KIAA1112 Background:Acts as guanine nucleotide exchange factor(GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
Molecular Weight
72 kDa
Gene ID
50649
UniProt
Q9NR80
Pathways
Neurotrophin Signaling Pathway
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