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RGMA antibody

RGMA Reactivity: Human, Mouse, Rat ELISA, WB, IP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7118468
  • Target See all RGMA Antibodies
    RGMA (RGM Domain Family, Member A (RGMA))
    Reactivity
    • 23
    • 3
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 22
    • 1
    Rabbit
    Clonality
    • 21
    • 2
    Polyclonal
    Conjugate
    • 9
    • 4
    • 3
    • 3
    • 2
    • 2
    This RGMA antibody is un-conjugated
    Application
    • 19
    • 19
    • 2
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunoprecipitation (IP)
    Purification
    Immunogen affinity purified
    Purity
    ≥95 % as determined by SDS-PAGE
    Immunogen
    RGM domain family, member A
    Isotype
    IgG
    Top Product
    Discover our top product RGMA Primary Antibody
  • Application Notes
    WB: 1:500-1:2000, IP: 1:200-1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Expiry Date
    12 months
  • Target
    RGMA (RGM Domain Family, Member A (RGMA))
    Alternative Name
    RGMA (RGMA Products)
    Synonyms
    RGM antibody, BC059072 antibody, C230063O06 antibody, repulsive guidance molecule family member a antibody, repulsive guidance molecule family member A antibody, RGMA antibody, Rgma antibody
    Background
    Synonyms:RGM Background:Member of the repulsive guidance molecule(RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein(BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
    Molecular Weight
    49 kDa
    Gene ID
    56963
    UniProt
    Q96B86
    Pathways
    Tube Formation
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