RSPO2 antibody

Catalog No. ABIN7118172

Product Details anti-RSPO2 Antibody

Target: RSPO2 (R-Spondin 2 (RSPO2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RSPO2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: R-spondin 2 homolog

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000, IP: 1:500-1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for RSPO2

Target: RSPO2 (R-Spondin 2 (RSPO2))

Alternative Name: RSPO2 (RSPO2 Products)

Synonyms: RGD1562331 antibody, CRISTIN2 antibody, 2610028F08Rik antibody, AA673245 antibody, D430027K22 antibody, ftls antibody, R-spondin 2 antibody, R-spondin 2 L homeolog antibody, Rspo2 antibody, rspo2.L antibody, rspo2 antibody, RSPO2 antibody

Background: Synonyms:CRISTIN2, hRspo2, R spondin 2, Roof plate specific spondin 2, RSPO2 Background:Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6(LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors.

Molecular Weight: 33 kDa

Gene ID: 340419

UniProt: Q6UXX9