POLR2D antibody

Catalog No. ABIN7117672

Product Details anti-POLR2D Antibody

Target: POLR2D (Polymerase (RNA) II (DNA Directed) Polypeptide D (POLR2D))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POLR2D antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: polymerase(RNA) II(DNA directed) polypeptide D

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:200-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for POLR2D

Target: POLR2D (Polymerase (RNA) II (DNA Directed) Polypeptide D (POLR2D))

Alternative Name: POLR2D (POLR2D Products)

Synonyms: wu:fa95b11 antibody, zgc:110435 antibody, HSRBP4 antibody, HSRPB4 antibody, RBP4 antibody, RPB16 antibody, 2310002G05Rik antibody, 2610028L19Rik antibody, RNA polymerase II subunit D antibody, DNA-directed RNA polymerase II 16 kDa polypeptide antibody, polymerase (RNA) II (DNA directed) polypeptide D antibody, Polr2d antibody, CpipJ_CPIJ006734 antibody, UREG_01395 antibody, LOC100282338 antibody, polr2d antibody, POLR2D antibody

Background: Synonyms: Background:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA(By similarity).

Molecular Weight: 16-20 kDa

Gene ID: 5433

UniProt: O15514

Pathways: Regulatory RNA Pathways