PAN2 antibody

Catalog No. ABIN7117214

Product Details anti-PAN2 Antibody

Target: PAN2 (PAN2 Poly(A) Specific Ribonuclease Subunit Homolog (PAN2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAN2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: PAN2 poly(A) specific ribonuclease subunit homolog(S. cerevisiae)

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for PAN2

Target: PAN2 (PAN2 Poly(A) Specific Ribonuclease Subunit Homolog (PAN2))

Alternative Name: PAN2 (PAN2 Products)

Synonyms: USP52 antibody, 1200014O24Rik antibody, AI047843 antibody, AW742773 antibody, Usp52 antibody, mKIAA0710 antibody, PAN2 antibody, pan2 antibody, PAN2 poly(A) specific ribonuclease subunit antibody, PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) antibody, PAN2 poly(A) specific ribonuclease subunit S homeolog antibody, PAN2 antibody, Pan2 antibody, pan2.S antibody

Background: Synonyms:KIAA0710, USP52 Background:Catalytic subunit of the poly(A)-nuclease(PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein(PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Molecular Weight: 127 kDa

Gene ID: 9924

UniProt: Q504Q3