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NMRAL1 antibody

NMRAL1 Reactivity: Human, Rat, Mouse ELISA, WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7116912
  • Target See all NMRAL1 Antibodies
    NMRAL1 (NmrA-Like Family Domain Containing 1 (NMRAL1))
    Reactivity
    • 11
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Rat, Mouse
    Host
    • 10
    • 2
    Rabbit
    Clonality
    • 12
    Polyclonal
    Conjugate
    • 8
    • 2
    • 1
    • 1
    This NMRAL1 antibody is un-conjugated
    Application
    • 7
    • 6
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
    Purification
    Immunogen affinity purified
    Purity
    ≥95 % as determined by SDS-PAGE
    Immunogen
    NmrA-like family domain containing 1
    Isotype
    IgG
    Top Product
    Discover our top product NMRAL1 Primary Antibody
  • Application Notes
    WB: 1:500-1:2000, IHC: 1:20-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Expiry Date
    12 months
  • Target
    NMRAL1 (NmrA-Like Family Domain Containing 1 (NMRAL1))
    Alternative Name
    NMRAL1 (NMRAL1 Products)
    Synonyms
    HSCARG antibody, SDR48A1 antibody, 1110025F24Rik antibody, AI256624 antibody, RGD1311451 antibody, NmrA like redox sensor 1 antibody, NmrA-like family domain containing 1 antibody, NMRAL1 antibody, Nmral1 antibody
    Background
    Synonyms:HSCARG Background:Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase(ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer.
    Molecular Weight
    33 kDa
    Gene ID
    57407
    UniProt
    Q9HBL8
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