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MCC antibody

MCC Reactivity: Human, Mouse ELISA, WB, IHC, IP, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7116539
  • Target See all MCC Antibodies
    MCC (Mutated in Colorectal Cancers (MCC))
    Reactivity
    • 42
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    Human, Mouse
    Host
    • 39
    • 3
    Rabbit
    Clonality
    • 41
    • 1
    Polyclonal
    Conjugate
    • 13
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MCC antibody is un-conjugated
    Application
    • 32
    • 15
    • 13
    • 13
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
    Purification
    Immunogen affinity purified
    Purity
    ≥95 % as determined by SDS-PAGE
    Immunogen
    mutated in colorectal cancers
    Isotype
    IgG
    Top Product
    Discover our top product MCC Primary Antibody
  • Application Notes
    WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Expiry Date
    12 months
  • Target
    MCC (Mutated in Colorectal Cancers (MCC))
    Alternative Name
    MCC (MCC Products)
    Background
    Synonyms: Background:Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase(PAK) activation(PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway(canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin(CTNB1) transcriptional activity(PubMed:24824780).
    Molecular Weight
    98 kDa , 113-118 kDa
    Gene ID
    4163
    UniProt
    P23508
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